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Despite the questionable efficiency of opioids in controlling CNCP and their significant costs of Unwanted side effects, the absence of accessible choice medicines and their scientific limitations and slower onset of motion has led to an overreliance on opioids. Conolidine is undoubtedly an indole alkaloid derived within the bark from the tropical

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Though the opiate receptor depends on G protein coupling for signal transduction, this receptor was observed to employ arrestin activation for internalization of the receptor. Otherwise, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted in variable enhancement in binding efficacy. This binding

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